Nolvadex (Tamoxifen) belongs to a category and class of drugs known as Selective Estrogen Receptor Modulators (SERMs). Selective Estrogen receptor modulators belong to an even broader class of drugs known as anti-estrogens. The other subcategory of drug under the anti-estrogens category is known as aromatase inhibitors (AIs), such as Aromasin (Exemestane) and Arimidex (Anastrozole). AIs and SERMs make up anti-estrogens Male dosage for Anapolan: Take 1 Tablet per day on cycle to block estrogen from the aromatasation of your anabolics. More than 20-40mg daily does not yield a greater effect. Female dosage: Take 1/2 - 1 tablet per day to manage estrogen when holding back water from anabolics or for estrogen control properties. • Should estrogen not go away, Refer to stronger blockers like Femara and Arimedex. • PLEASE NOTE that dosages may vary from person to person and depending on what the Nolvadex would be used for. (GYNO, PCT etc..) NOLADEX 20mg TAMOXIFEN Detection Time 5-7 days Terminal elimination half-life: 5-7 days. *PLEASE NOTE* NO PCT PROTOCOL IS REQUIRED AFTER CYCLE.
Description Anastrozole 1mg / tab 50 tabs Anastrozole is an extremely powerful anti-estrogen officially belonging to the Aromatase Inhibitor (AI) family. Developed in the early 1990’s by Zenaca Pharmaceuticals and released in 1995 under the trade name Arimidex, this is perhaps the most commonly used AI and one of the most common anti-estrogens on the market. Arimidex has proven to be very effective in breast cancer treatment, even more so than traditional Nolvadex (Tamoxifen Citrate), and is a favorite anti-estrogen among many anabolic steroid users. Countless anabolic steroid users rely on Arimidex for on cycle estrogenic protection. Many anabolic steroids have the ability to aromatase and lead to excess estrogen, which in turn can lead to some of the most commonly associated side effects of anabolic steroid use. Arimidex Functions & Traits: The functions and traits of Arimidex although powerful are extremely simple. As an AI Arimidex functions by blocking the aromatase enzyme, which is in turn responsible for the production of estrogen. By inhibiting the aromatase process, Arimidex will lower the body’s serum estrogen levels; in fact, a total suppression of estrogen by 80% has been well noted with this AI. This will prove very beneficial to numerous breast cancer patients and extremely valuable to many anabolic steroid users. Arimidex also has the ability to stimulate the release of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), two hormones essential to natural testosterone production. This has led some physicians to use the AI in low testosterone treatment plans in place of testosterone, but it’s generally not the best choice. Arimidex in a low testosterone plan is generally better served in conjunction with testosterone therapy. We will look more into this when we discuss the effects of Arimidex later on. Effects of Arimidex: As an anti-estrogen, Arimidex is valuable to the breast cancer patient as many forms of breast cancer feed off of the estrogen hormone. While perhaps an oversimplification, by administering Arimidex the effect starves the cancer. For decades Nolvadex was used for this purpose. Nolvadex has the ability to bind to the estrogen receptors, which in turn prevents estrogen from binding. However, AI’s like Arimidex actively inhibit the production of estrogen and reduce the actual amount of circulating hormone. In short, there is no estrogen available to cause damage to the breast cancer patient. In recent years, Arimidex has become the leading anti-estrogen in the treatment of hormone receptor-positive breast cancer, especially among post-menopausal women. Once the cancer has subsided, it is not uncommon for Nolvadex to be introduced in order to keep the cancer at bay. For the anabolic steroid user, the effects of Arimidex are greatly appreciated in its ability to protect against estrogenic related side effects. Many anabolic steroids have the ability to promote estrogenic side effects due to the testosterone hormone’s interaction with the aromatase enzyme. As aromatization occurs, estrogen levels rise and this can lead to gynecomastia and excess water retention. When excess water retention becomes severe, this can also promote high blood pressure. Not all anabolic steroids aromatize, and as such, not all can lead to estrogenic related effects. However, many common steroids do carry the ability to promote estrogenic activity including Dianabol, all forms of Nandrolone and Boldenone to a degree and of course, all forms of testosterone heavily. By including Arimidex in an anabolic steroid cycle that contains aromatizing steroids, the individual can protect against gynecomastia and water retention. This will also protect against high blood pressure. Some steroids can still cause high blood pressure without water retention, but heavy excess water retention is the number one culprit of high blood pressure among anabolic steroid users. Without question, AI’s like Arimidex are the most effective anti-estrogens for combating estrogenic related side effects. SERM’s like Nolvadex can also be useful and while not as effective should be the first choice when possible. Arimidex has the ability to negatively affect cholesterol as we will see in the side effects section. However, we will also find cholesterol issues can be avoided. As a testosterone stimulating compound, Arimidex can be appealing for low testosterone treatment plans and for Post Cycle Therapy (PCT) for anabolic steroid users. In the case of low testosterone treatment, it’s often not enough. However, it can still be beneficial in conjunction with exogenous testosterone therapy in protecting against estrogenic side effects. As for PCT use, some will attempt it and it can have a positive effect, but it is generally not recommended. The main purpose of a PCT plan is to stimulate natural testosterone production in order to protect lean muscle tissue, keep body fat under control and promote a better state of health. However, the overall purpose is normalization, which cannot be reached when using Arimidex post cycle due to the tremendous estrogen reduction. Although high levels of estrogen can be problematic, some is necessary to proper bodily function, especially regarding the immune system and cardiovascular health. For the anabolic steroid user, AI’s should be saved for on cycle use with SERM’s being used for PCT. Side Effects of Arimidex: Arimidex carries with it several possible side effects. Many of the side effects of Arimidex will be response related. Response side effects are common with all medications; some of us can take Aspirin while others can’t. The side effects of Arimidex will also vary depending on anabolic steroid use in a few specific areas. Those who are using Arimidex without anabolic steroids often report weakness and fatigue; in fact, this may be the most common side effect of Arimidex. Most anabolic steroid users will not have this issue with low dose Arimidex use. However, we can make an exception when it is used in hard cutting or competition cycles when calories are very low and training often extremely intense. Other possible side effects of Arimidex use include: Headache Hot Flashes High Blood Pressure Joint Pain Depression (rare) Nausea and or Vomiting (rare) Arimidex studies have also shown that the AI may have the ability to decrease bone mineral content, which in turn could make the individual more susceptible to osteoporosis. This shouldn’t be a big issue for anabolic steroid users as many anabolic steroids have the ability to promote bone mineral content. As for the primary six possible side effects of Arimidex listed above, while possible most adults should be able to use the AI without any related issues, but keep in mind such issues are possible. We all respond to varying medications differently, we even respond to varying foods differently, which can make total response on an individual basis impossible to fully predict. The final issue revolving around the side effects of Arimidex surrounds cholesterol. Arimidex does have the ability to negatively effect cholesterol levels, but alone it doesn’t appear to be significant in most cases. However, when conjoined with anabolic steroid use, specifically an aromatizing steroid like testosterone it appears to be significant. For example, studies have shown that a moderate dose of Testosterone Enanthate for 12 weeks does not appear to have a strong affect on cholesterol. However, when this same dose is coupled with an AI like Arimidex it can suppress HDL cholesterol by as much as 25%. In this case, we’re actually talking about therapeutic level doses as well as performance. True performance doses of testosterone will have a stronger impact on HDL cholesterol, and again around a 20% decrease in HDL when conjoined with an AI. Due to the potential cholesterol issues brought on by Arimidex use by the anabolic steroid user, a healthy and cholesterol friendly lifestyle is extremely important. A healthy lifestyle should first and foremost surround your diet. Diets should be low and very limited in saturated fats and simple sugars. They should also be rich in omega fatty acids. Daily fish oil supplementation is advised. It’s also worthwhile to consider the use of a cholesterol antioxidant supplement. And as a final note, if cardiovascular health is to be protected the individual should always incorporate plenty of cardiovascular training into his routine. Daily cardiovascular activity is recommended. Due to the possible cholesterol issues, moderate anabolic steroid cycles may be best served with SERM’s in order to protect against estrogenic related side effects. SERM’s will not negatively affect cholesterol; in fact, SERM’s like Nolvadex have been shown to promote healthy cholesterol levels due to their ability to act as estrogen in the liver. However, for many a SERM won’t be enough and AI’s will be necessary. If an AI is necessary, the individual should limit his use and only use as much as is actually needed. Some have suggested that a 10mg per day dosing of Nolvadex along with your Arimidex use may actually aid in cholesterol management. Arimidex Administration: In the treatment of breast cancer, Arimidex is almost always dosed at 1mg per day until the cancer subsides. Use may continue for a time at this stage and will often be switched to Nolvadex in a preventative measure once the cancer is in remission. For the anabolic steroid user, Arimidex doses can vary with 0.5-1mg every other day being the most common. Very few should ever need more than 1mg every other day and many will be more than fine with half that amount. In therapeutic plans such as low testosterone treatment even less may be needed. We can, however, make an exception in Arimidex doses for competitive bodybuilders. Competitive bodybuilders may find a full 1mg every day the last 10-14 days leading up to competition to be useful. This will greatly aid in hardening, but it will be draining to say the least. Of course, at this stage of a competition diet most have very little energy to begin with anyway. Side Effects of Arimidex: Arimidex carries with it several possible side effects. Many of the side effects of Arimidex will be response related. Response side effects are common with all medications; some of us can take Aspirin while others can’t. The side effects of Arimidex will also vary depending on anabolic steroid use in a few specific areas. Those who are using Arimidex without anabolic steroids often report weakness and fatigue; in fact, this may be the most common side effect of Arimidex. Most anabolic steroid users will not have this issue with low dose Arimidex use. However, we can make an exception when it is used in hard cutting or competition cycles when calories are very low and training often extremely intense. Other possible side effects of Arimidex use include: Headache Hot Flashes High Blood Pressure Joint Pain Depression (rare) Nausea and or Vomiting (rare) Arimidex studies have also shown that the AI may have the ability to decrease bone mineral content, which in turn could make the individual more susceptible to osteoporosis. This shouldn’t be a big issue for anabolic steroid users as many anabolic steroids have the ability to promote bone mineral content. As for the primary six possible side effects of Arimidex listed above, while possible most adults should be able to use the AI without any related issues, but keep in mind such issues are possible. We all respond to varying medications differently, we even respond to varying foods differently, which can make total response on an individual basis impossible to fully predict. The final issue revolving around the side effects of Arimidex surrounds cholesterol. Arimidex does have the ability to negatively effect cholesterol levels, but alone it doesn’t appear to be significant in most cases. However, when conjoined with anabolic steroid use, specifically an aromatizing steroid like testosterone it appears to be significant. For example, studies have shown that a moderate dose of Testosterone Enanthate for 12 weeks does not appear to have a strong affect on cholesterol. However, when this same dose is coupled with an AI like Arimidex it can suppress HDL cholesterol by as much as 25%. In this case, we’re actually talking about therapeutic level doses as well as performance. True performance doses of testosterone will have a stronger impact on HDL cholesterol, and again around a 20% decrease in HDL when conjoined with an AI. Due to the potential cholesterol issues brought on by Arimidex use by the anabolic steroid user, a healthy and cholesterol friendly lifestyle is extremely important. A healthy lifestyle should first and foremost surround your diet. Diets should be low and very limited in saturated fats and simple sugars. They should also be rich in omega fatty acids. Daily fish oil supplementation is advised. It’s also worthwhile to consider the use of a cholesterol antioxidant supplement. And as a final note, if cardiovascular health is to be protected the individual should always incorporate plenty of cardiovascular training into his routine. Daily cardiovascular activity is recommended. Due to the possible cholesterol issues, moderate anabolic steroid cycles may be best served with SERM’s in order to protect against estrogenic related side effects. SERM’s will not negatively affect cholesterol; in fact, SERM’s like Nolvadex have been shown to promote healthy cholesterol levels due to their ability to act as estrogen in the liver. However, for many a SERM won’t be enough and AI’s will be necessary. If an AI is necessary, the individual should limit his use and only use as much as is actually needed. Some have suggested that a 10mg per day dosing of Nolvadex along with your Arimidex use may actually aid in cholesterol management. Arimidex Administration: In the treatment of breast cancer, Arimidex is almost always dosed at 1mg per day until the cancer subsides. Use may continue for a time at this stage and will often be switched to Nolvadex in a preventative measure once the cancer is in remission. For the anabolic steroid user, Arimidex doses can vary with 0.5-1mg every other day being the most common. Very few should ever need more than 1mg every other day and many will be more than fine with half that amount. In therapeutic plans such as low testosterone treatment even less may be needed. We can, however, make an exception in Arimidex doses for competitive bodybuilders. Competitive bodybuilders may find a full 1mg every day the last 10-14 days leading up to competition to be useful. This will greatly aid in hardening, but it will be draining to say the least. Of course, at this stage of a competition diet most have very little energy to begin with anyway.
Letrozole (Femara) belongs to a category and class of drugs known as aromatase inhibitors (AIs). Aromatase inhibitors belong to an even broader class of drugs known as anti–estrogens. The other subcategory of drug under the anti-estrogens category is known as selective estrogen receptor modulators (SERMs), such as Nolvadex and Clomid. AIs and SERMs make up anti-estrogens. Male dosage: Should Gynecomastia be present in males , 1 tab of Femara should be taken until Gyno is reduced or completely gone, thereafter 1 tab every other day should be taken to maintain low estrogen levels. Female Dosage: 1 Every other day should estrogen levels be too high. But femara is quite strong thus Nolvadex is the preferred option for females. PLEASE NOTE that side effects like hot flashes, mood swings, depression, low libido, headaches etc. may occur because of low estrogen levels. Half life 2 days *PLEASE NOTE* NO PCT PROTOCOL IS REQUIRED AFTER CYCLE.
KETOTIFEN 1MG/TAB 50 TABS
Proviron is the trade / brand name for the androgen known as Mesterolone. It is an oral product, and is not considered an anabolic steroid. This is because its anabolic activity is known for being extremely weak – so weak, in fact, that it can be practically considered nonexistent. Proviron was initially developed by Schering in 1934, making it one of the oldest steroids manufactured and marketed for medical use. Male dosage: Common used dosage is 1 Tab morning and 1 Tab Evening while on cycle to boost natural test as well as balance hormones and control water retention. Some users taper up dosage to 100mg a day. Females can take1 tab per day for the same reason while using anabolics to prevent water retention and balance hormones. Half life 13 hours *PLEASE NOTE* NO PCT PROTOCOL IS REQUIRED AFTER CYCLE.
Clomid (Clomiphene Citrate) belongs to a category and class of drugs known as selective Estrogen receptor modulators (SERMs). Selective Estrogen receptor modulators belong to an even broader class of drugs known as anti-estrogens. The other subcategory of drug under the anti-estrogens category is known as aromatase inhibitors (AIs), such as Aromasin (Exemestane) and Arimidex (Anastrozole). AIs and SERMs make up anti-estrogens. Clomid Dosage depends on reason for usage . Usually doing a PCT, 50-100mg of Clomid for the first 5 days of PCT and the last 5 days of PCT will be sufficient (Some users use the 5 days on, 5 days off method). Females would take 50mg per day for inducing ovulation. While in males it increases the sperm count and switches natural test production back on. • Usually stacked with Nolvadex and Pregnyl as part of a PCT protocol. Half life 5 days *PLEASE NOTE* NO PCT PROTOCOL IS REQUIRED AFTER CYCLE.
METHASTERONE Methasterone, also known as Superdrol or methyldrostanolone is one of the strongest orally active anabolic-androgenic steroid (AAS) out there. Methasterone (Superdrol) was created back in the 1950s but was never commercially available as a prescription drug. Superdrol Cycles There are various approaches you can take when it comes to running Superdrol cycles. A typical start dosage of 10-20mg and more enhanced dosage of 20-30mg maximum of 40mg . It’s highly advised to run a test base with this compound like test prop ,sus250 , test e , test combo 350/450 and or deca100/300 , equipoise and tren100/200 • Cycle periods 4-6weeks . • Pct protocol should follow after a cycle . • Most common side effect of SD is libido drop thus the use of a test in cycle is advise to prevent this from happening.
DHEA (dehydroepiandrosterone) 25mg per tab 50 tabs DHEA (dehydroepiandrosterone) is a natural, intermediate steroid hormone that is produced in our body by the adrenal glands. DHEA is the most abundant hormone in our blood and can be taken by both men and women due to the fact that we both produce it within our bodies. DHEA levels in our blood are crucial for many hormonal and metabolic functions in our body. As we age we produce less and less DHEA and as a result our blood DHEA level gets lower and lower. This may make us gain more body fat, dry our skin, decrease sex drive, and affect our memory. When adding or supplementing DHEA to our bodies when our blood DHEA levels are low, we can improve these problems and may be able to live longer lives. DHEA is used for a variety of reasons. It can: • Add More Muscle Mass • Improve Sexual Function • Increase Memory • Decrease Body Fat • Enhance Athletic Performance • Help With Depression.
METHENOLONE ACETATE Primobolan is the trade name for the anabolic steroid Methenolone (also written as Metenolone). It is available in both an injectable oil-based format, as well as an oral form. Injectable Primobolan is known as Methenolone Enanthate, and the oral format is known as Methenolone Acetate. Male Dosage: 100-200mg daily for a period of 8-10 weeks, In such an environment the anabolic effect of Primobolan tabs can develop to its optimum. Masteron, Parabolan, Equipoise, and Winstrol, are particularly suitable to stack. Female dosage: 50-100mg for a period of 6-8 weeks. Can be stacked with Winstrol, Anavar and/or Clenbuterol for optimal results. • Mostly used as a hardening agent in contest prep. • Effectiveness will only be seen on low bodyfat %. Usually 15% and lower. • Minimal side effects on recommended dosages (Especialy in female users). Detection Time 4 weeks Half life 10 days *PLEASE NOTE* 14 Days after all cycles a PCT protocol should be followed to restore all natural hormones back to normal.
Methyltrienolone 250MCG/TAB 50 TABS Effective dosage starts of Oral Tren at 25 mcg. Relatively safe can be considered a daily dosage of 500-750 mcg; by its effectiveness, it is more or less comparable with 150-225 mg of Trenbolone Acetate. It is not recommended to take more than 1 mg of the Oral Tren per day. It is not recommended to take the Oral Tren for longer than 3-4 weeks in a row. In connection with the high risk of virilization, for women it is better to avoid Oral Tren
OXANDROLONE Anadrol is known as being one of the contenders for being the strongest oral anabolic steroid commercially available. It closely competes with Dianabol, and steroid-using bodybuilding circles have always debated which of the two are stronger. Male dosage for Anapolan: 50-150 mg per day split into two dosages 8 hours apart. Anapolan is usually used for 4 weeks. Intended use is for bulking, strength-gaining, and general overall mass. Female dosage: 25-50 mg per day should be sufficient - Always take Anapolan with an organ support as it has high liver toxicity. - Stacks well with Testosterone/ Sustonan and/or Deca and/or Trenbolone. - Anadrol is usually used as a kickstarter for 4-6 when starting a new anabolic cycle or added mid cycle to push through plateus. Detection time: 2 Months *Please note* PCT PROTOCOL IS REQUIRED AFTER CYCLE
OXANDROLONE Anavar is the trade name for the oral anabolic steroid Oxandrolone, which is the generic chemical name. Anavar was developed and marketed during the height of anabolic steroid research between the 1950s and the 1980s. It is the apex of the never-ending quest to discover and develop an anabolic steroid that could be considered perfect. Oxan 50mg is more suitable for male users as the active dosage for males are 50-100mg daily(Competetive users will use up to 150mg a day for a short duration). A stack of 200 mg Deca/week, 500 mg Testosterone enanthate (e.g.Test Enanthate)/week, and 50- 100mg Oxandrolone/day leads to a good gain in strength and mass in most athletes. Deca has a distinct anabolic effect and stimulates the synthesis of protein; Oxandrolone improves the strength by a higher phosphocreatine synthesis; and Testosterone enanthate increases the aggressiveness for the workout and accelerates regeneration. • Mostly used for adding lean muscle mass, full benefits can be seen on bodyfat lower than 20%. • Tren Acetate can be a suitable replacement for Deca depending on the user’s desired result. • Minimal side effects on recommended dosage. Detection Time 3 weeks Half life 11 hours *PLEASE NOTE* 14 Days after all cycles a PCT protocol should be followed to restore all natural hormones back to normal.
METHYL-1-TESTOSTERONE THE STRONGEST ORAL COMPOUND EVER MADE. Because of its potency V.Med formulated it in a 5mg capsule and put 90 capsules in a container. Taking one capsule/day (5mg) should be sufficient. At most two capsules/day (10mg) for a maximum of 5 to 6 weeks. These doses might sound low but it is potent. We warn athletes to not compare it to other products they are familiar with. Some users reported a dose of around 20mg to be very high. Side effects of high blood pressure and toxicity at those dosages became clear. Action Some describe M1T’s characteristics as a mix between Primobolan, Stanazol, and Trenbolone. I like comparing it to Oxymetholone (Anapolon) by comparing anabolic ratings. Anapolon is one of the strongest orals in the world. It has an anabolic rating of 320. M1T has an anabolic rating of 900-1600. Between four and five times the anabolic rating of Anapolon (Oxymetholone) The active ingredient is methyl-dihydroboldenone. Also known as Methyl-1-testosterone or M1T. It is a derivative of dihydrotestosterone. Effects When the rapid mass gain is the aim of bulking cycles M1T is used. Many athletes report water retention on M1T. Athletes who are genetically lean report massive pumps and extreme vascularity when working out in the gym. After as little as two days the toxicity can be felt M1T is most potent when used as an anabolic and androgenic on its own. Stacked with regular agents. An injectable testosterone enanthate, cypionate or even a Test 450mg Combo from Ciccone Pharma. That will pack a serious punch and add to serious gains. 1ml of Test450mg Combo 2-3/week with 2-3 capsules of M1T/day is a serious stack. For serious gains. M1T is not well-known and very new to the market. Athletes who want something different to their normal compounds this a highly recommended bulking agent. Milligram for milligram it is also two to three times stronger than Superdrol.
FLUOXYMESTERONE Halotestin is a synthetic derivative of Testosterone, but it is in particular actually a derivative of Methyltestosterone (Testosterone that has been Methylated). It is generally regarded as a very strong oral anabolic steroid that is unable to aromatize into Estrogen and also exhibits very strong androgenic strength as well. Halotestin in particular possesses an anabolic strength rating of 1900 and an androgenic strength rating of 850. Male Dosage: Usually, 20-30 mg/day will satisfy bodybuilders. While power lifters often take 40 mg a day or more. They split the daily dose into two equal amounts and taken mornings and evenings with plenty of fluids. • Stacks well with Anavar, Deca100, Primobolan Depot, or Equipoise or any other drug used in preperation for a bodybuilding competition. • Bodybuilders usually use halotestin 4 weeks out from a competition to help them power through the depletion phase of their preperation. • Commonly used among powerlifters as it greatly increases strenght. • For Powerlifters halotestin is stacked well with Deca and high doses of testosterone. Side effects: Liver and kidney damage are most likely on high dosages. Irritability
CHLORODEHYDROMETHYLTESTOSTERONE Turinabol (Chlorodehydromethyltestosterone, also known as ‘Tbol’ and Oral Turinabol) is actually a modified form of Dianabol (Methandrostenolone), whereby it is actually a combination of the chemical structures of Dianabol and Clostebol (4-chlorotestosterone). Hence this is why the actual chemical name is 4-chlorodehydromethyltestosterone. Male Dosage: 50-70mg Per day for a period of 8-10 weeks . • Stacks well with most anabolics and any testosterone. • Common among users that does not want to inject. Female dosage: 20-40mg per day for 6-8 weeks. • Highly recommended only for females competing in divisions needing a more mascular physique. • Stacks well with Primabolan , Winstrol or Clenbuterol. Detection Time 4-6 months Half life 16 Hours *PLEASE NOTE* 14 Days after all cycles a PCT protocol should be followed to restore all natural hormones back to normal.
METHANDROSTENOLONE Dianabol, known by its scientific and chemical name as Methandrostenolone (and/or Methandienone), is the most popular and widely utilized anabolic steroid by bodybuilders and athletes today. It gained its popularity in the late 1950s and throughout the “Golden Era of Bodybuilding” of the 1960s and 1970s. Male Dosage: Active dosage in males are between 50-100mg per day for a period of 8 weeks • Stacked with Test E/Sus/TC450 as a base and added anabolics like Deca/Equipoise/Primabolan and/or Parabolan. • Proviron and Nolvadex should also be added due to the aromatasation properties of Dianabol. Detection Time 6 weeks Half life 3-6 hours
STANOZOLOL Winstrol is the trade name and brand name for the anabolic steroid more formally and properly known as Stanozolol. It exists in both an oral and injectable format, and it sits on the third place pedestal among the top 3 anabolic steroids most widely used and most popular among bodybuilders and athletes. Male dosage: Active dosage in males are 50-100mg per day for no longer than 6 weeks at a time. Winstrol can be incorporated into most anabolic cycles. Female dosage: 10-30mg per day have shown significant changes in muscular physique in woman. • Winstrol has a high liver toxity rating and should be taken with a liver support. Cholesterol should also be monitored while using this compound. Detection Time 3 weeks Half life 9 hours
LGD-4033 (Ligandrol) is a very powerful SARM that can help you reach your full potential. Let’s get to know more about this non-steroidal product. What is LGD-4033? LGD-4033 is one of the newer SARMS that has come out. It is a non-steroidal oral SARM that binds with AR which produces steroid-like results minus the steroids. It is the closest SARM that can be equated to an anabolic in terms of strength. LGD-4033 is the strongest of all the SARMS in terms of the size you can gain. It’s in a group of androgen receptor (AR) ligands that are tissue selective, created to cure muscle wasting linked with acute and chronic diseases, age-related muscle loss and cancer. LGD-4033 is anticipated to yield the healing benefits of testosterone with better safety, admissibility and patient acceptance due to tissue-selective mechanism of action and its oral form of administering. LGD-4033 is 98.41% PURE as shown in the lab report below confirming that the purity and structure in LGD 4033 is of the absolute highest quality. How LGD-4033 Works LGD-4033 works by tying androgen receptors selectively. It shows anabolic activity in the bones and muscles instead of harmfully affecting the prostate and sebaceous glands which usually happens when using steroids. LGD-4033 just concluded a study called Phase I Multiple Ascending Dose which included fit volunteers. This was an unplanned, double bind analysis stage that included a placebo. The objective was to form that using LGD-4033 was harmless and easy to stomach with a dose not beyond 22 mg a day. Clinical runs also showed that LGD-4033 has the ability to set off the following benefits when taken consistently: An increase in strength levels Lean muscle mass improved A drop in body fat Has healing properties Does not cause the undesirable side effects caused by prohormones and anabolic steroids When to Use LGD-4033 Based on some latest studies and experiments conducted, Ligandrol can enhance lean muscle mass and decrease body fat. Also, it can boost strength for better and more challenging training performance, recovery and overall health. Thus, it comes as no surprise that athletes and bodybuilders use LGD-4033 to help them be in their best selves. For Bulking Suggested dosage is 5-10 mg a day for 8 weeks. A protein-rich diet is also necessary as well as higher caloric intake if you plan to beef up by 10 pounds or more. For Cutting Use LGD-4033 with SARMS triple pack (GW-501516, S-4 and LGD-4033) to make it more effective as you are aiming to add more size while cutting fat. Suggested dosage is 3-5 mg a day for 8 weeks. For Recomping LGD-4033 is best used for recomping. Many users have said that they’ve observed a boost in lean body mass and fat loss. Using it together with other SARMS such as GW-501516 or Cardarine will give you a stronger and better recomp. Suggested dosage is 5-8 mg per day for 8 weeks. Does LGD-4033 Have Any Side Effects? It is non-toxic and the side effects are very minimal. Thus, using LGD-4033 is recommended if you want to bulk up and drop fat sans steroids as we all know steroids have harsh side effects. It won’t affect your liver but a full PCT is advised after running LGD-4033. The suppression is higher than other SARMS (but lower than anabolics), thus the need for PCT.
S4 (Andarine) or Acetamidoxolutamide, is a SARM (Selective Androgen Receptor Modulator). S4 is said to be the most potent SARM which helps sustain lean muscle mass while stimulating fat elimination at the same time. Today, we’ll take a closer look on everything there is to know about S4. What is S4? To start, let’s describe what a SARM does. There are three type of chemicals that act on the androgen receptor (AR). One is the an AR antagonist, which is a chemical that binds to the receptor to prevent it from activating. The second is an AR agonist, which binds to the receptor and detaches, then binds again, over and over. An example of an AR agonist is testosterone, each time the AR is bonded with testosterone, a signal is sent out to activate a particular set of genes. The more testosterone that is in the system, the more AR binding will occur. The third is an AR modulator, or basically a molecule that attaches to an AR and changes its structure to react however it wants. How S4 Works A SARM such as S-4 is a good example. S-4 attaches to the AR and sticks to it; each time the AR interacts with testosterone, S-4 forces it to produce genes that exclusively benefit muscle and bone growth. In other words, S4 is a form of SARM that attaches to the androgen receptor (AR) the same with regular androgens, the only variation is that S4 generates selective anabolic activity. s4-andarine-chemical-structureS4 Chemical Composition As said earlier, SARMS function by tying to the AR resulting to anabolic activity. Due to this fastening and stimulation, more protein is produced which allows muscle building. S4 can trigger muscle development in the same way as steroids, but minus the same unwanted side effects, the latter has on the prostate and other sexual organs. S4 is a SARM with utmost androgenic effects as it around 33% of the strength of testosterone when attaching to AR. S-4 also increases the amount of muscle mass produced by desensitizing the AR to the individual’s natural testosterone to influence a stronger effect. S-4 is by far the most versatile SARM ever created. Not only is it the first SARM approved for a stage 2 research study, it has become the most analyzed and investigated SARM so far. After the discovery of its anabolic potential, the primary purpose of S-4 aimed to develop an alternative treatment to age-related muscle wasting, osteoporosis, and similar symptoms of hypogonadism, or end-stage renal disease. Aside from preserving lean body mass, S4 can also help improve it. From a stage 1 study, S-4 has provided evidence of a 3.3 lbs increase in less than 90 days with no increases exercise or change in daily diet. An unintended side effect (or benefit if you will) is the decrease in body fat [Chen et al., 2005; Gao et al., 2005; Kearbey et al., 2007]. Decreases in body fat are dependent on the person’s genetics, but it will definitely have strong effects on the body’s ability to oxidize fatty tissue. S-4 was found to not only have a great affinity (potency in binding to androgen receptors), while also presenting greater anabolic effects than some traditional steroids [Kearbey et al., 2007]. Aside from its muscle building advantages, S4 won’t cause liver damage, can prevent gynecomastia (enlarged breasts in men) and can help boost your overall health. History and Development of S4 The idea for S-4 didn’t start out as many believe. It wasn’t an attempt to create a safer version of steroids or any of that nonsense people use to sell anabolics. S-4 started out as a new development for male contraceptives and showed some promising effects. There had been decreases in spermatogenesis and an increase in male libido. So for those of you who have had trouble getting your wife pregnant while on sarms…you’re welcome. It wasn’t until researchers discovered how this first generation SARM affected castrated lab mice by not only increasing the production of muscle mass and calcium for bone density, but was also completely selective in its tissue growth. As studies continued, many of these research trials resulted in astonishing outcomes creating a benchmark for even more research. One study in particular compared S-4 to DHT (a common anabolic steroid); the results have shown that S-4 exceeded DHT in producing lean muscle mass over the course of 120 days with only 3mg per day. S-4 has also shown no side effects on prostate growth, testosterone shut down, or any negative side effects caused by traditional anabolic steroids [Kearbey et al., 2007]. Another study identified that S-4 is completely absorbed even at very low doses. The half-life for S-4 is between 2.6 to 5.3 hours. Most people have opted to split their 50mg to 75mg doses into 3 separate doses, one with every meal. This has become somewhat of a dogma but there are now studies proving that it is any more effective than one solid dose once a day [Chen et al., 2005a; Gao et al., 2004; Gao et al., 2005; Kearbey et al., 2007; Kearbey et al., 2004]. Once more, an early study done on S-4 provided proof of full muscle regeneration in volunteers with with degenerative disorders without the use of exercise and the minimum dosage of 3mg/kg/day. Changes can be seen anywhere from 1-2 weeks. This was the very first study classified S-4 as CLINICALLY SIGNIFICANT by improving skeletal muscle strength, lean body mass, and a reduction in body fat [Chen et al., 2005; Gao et al., 2005; Kearbey et al., 2007]. Unfortunately, there are always some side effects that arise when using Because S-4 is a ligand by definition, the side effects will never be permanent even at supraphysiological dosages and can be easily avoided through proper dosing. How Andarine is used will depend on the kind of results you want. Here are the general guidelines… Right Dosing S-4 should be taken at 50mg-75mg, 5 days out of the week, for 12-16 weeks. As mentioned before, S-4 does not need to be taken on 3 separate occasions throughout the day; but for individuals that prefer this method, a 25mg dose (roughly half a milliliter) is recommended once with each of your three main meals. Once again, as mentioned above, S-4 does have point of diminishing returns. This means usage of S-4 passed 75mg or usage of S-4 for more than 16 weeks will not result in any added muscle mass. There will not be an increase in side effects either, but you will be running the risk of AR desensitization and inevitably wasting your product. Dosing with S-4 for less than 6-8 weeks is not recommended and will not allow the researcher to witness the full benefits of the product. Recommended dose for cutting is 50 mg for 6-8 weeks. You should use it every day then take 2 days off for the duration. Taking S4 daily for the length of the cycle can lead to changes in eyesight. Uses of Andarine For Cutting (best use of S4) Andarine’s properties are very alike with steroids Anavar and Winstrol, the only difference is that S4 can better provide lean muscle gains. In fact, there have been many cases of bodybuilders gaining up to 3 pounds of lean muscle while on a caloric deficit! S4 displays the same binding resemblance to AR, hence presenting similar fat burning effects. S4 can also minimize LPL (lipoprotein lipase) – an enzyme that causes lipid accumulation and plays a role in storing adipose tissue (excess body fat). The AR oxidizes this adipose tissue and uses it as its preferred energy source, allowing the body to decrease excess fat at an amazing rate. It also improves vascularity for that “aesthetic” chiseled look with minimal to no water retention. Unlike steroids, it won’t affect your joints but reinforce muscle mass and power instead. You can also say goodbye to painful pumps. Recommended Dosage: 50 mg for 6-8 weeks. *Take 2 days off when taking S4 (repeat the cycle after the 2 day break) to avoid vision side effects. For Recomping Use S4 with a more anabolic SARM such as Ostarine for better recomp results as you’re aiming to gain muscle while losing fat. Recommended intake is 50-75 mg for 4 to 8 weeks. For Bulking S-4 isn’t the sarm that comes to mind when we think “BULKING”, but it’s properties in muscle gain shouldn’t be overlooked. During the holiday season, many people take advantage of the excess food and snacks available and jump on some well known bulking SARMs such as LGD 4033 or RAD 140. While there isn’t an enormous 15 lb leap in muscle like these “bulk specific” products, S-4 can provide relatively large muscle gains and utilize these excess calories to provide an extra 8-10 lbs in muscle while also keeping the body relatively lean. This steady increase in muscle mass can limit the amount of work one needs to do for a leaner summer body. The Benefits of S4 over Steroids Very minimal growth on secondary sexual organs such as the prostate. The LDL/ HDL ratio is not affected which makes it a low cardiovascular risk. 0% chance of aromatization, male breast lactation, or rise in any other female characteristic during the post cycle recovery. Testosterone is not diminished in any capacity during the post cycle recovery. Very exclusive in tissue selection and growth which means it will not cause heart enlargement or damage to neighboring organs. SARMs do NOT require the utilization or devouring of liver enzymes to activate their anabolic effects. This eliminates any risk of hepatotoxicity or hepatitis. Although SARMs such as S-4 are not as powerful as comparable steroids such as Winstrol, they do not require the extensive post cycle therapy and can be cycled back to back throughout the year. Over the course of a year, obtaining the same results is very possible. SARMs is very female friendly and does not cause excessive masculine features such enlarged sexual characteristics. S-4 has overall presented larger increases in muscle mass than DHT. S4 Side Effects Unfortunately, S-4 isn’t the perfect anabolic chemical and does come with some down sides. The first and possibly the most disappointing is that it follows the law of diminishing returns. Unlike anabolic steroids, sarms will become continuously less effective after a certain milligram percentage. For the average person it ranges from 50mg to 75mg. there are people that can go above this range for even more amazing results or need to stay below this range because they are unable to tolerate the chemical. About 99.5% of the population should fall within the 50mg to 75mg range. The most popular negative effects of S-4 are visual issues such as the yellow tint and difficulty adjusting to night vision. These side effects are unique to S-4 and are sometimes overblown. If these side effects present themselves, simply stop taking S-4 for two days and stay at a 5 day on/ 2 day off cycle. THESE EFFECTS ARE NOT PERMANENT! Once a ligand (such as a SARM) leaves the system, it’s effects disappear completely. Lastly, S-4 and most other SARMs have been known to cause depression in a small population of people. This has been discovered as more of a psychological issue than a physiological issue. researchers with mice suffering from any emotional disorders need to be cautious when using this chemical.
GW 501516 (or Cardarine) is a research chemical developed in the 1990s to prevent and cure tumour formation in the colon, prostate, and breasts. Studies done in the early 2000s have found that GW 501516 and other PPAR agonists have also been able to stop metabolic disorders such as obesity and diabetes through specific gene expressions. As research continued to grow, bodybuilders quickly caught on to GW 501516, calling it the ultimate endurance enhancing supplement. GW’s ability to burn off excess fatty tissue, enhance recovery, and dramatically increase endurance has made this product a staple in every athlete’s cycle and PCT. With no harmful side effects found in the past 20 years, no wonder why GW 501516 has become a legend in the world of sports and athleticism. Let’s take a closer look… The Benefits of GW 501516 GW 501516 is the “ultimate endurance enhancer” – It’s used by elite athletes and competitors for a reason. Gives you insane energy levels – so you can push harder in the gym, increase your intensity, and bust through plateaus like never before. Decreases recovery time – meaning you can lift almost every day while taking GW. Will rapidly melt fat, but is NON CATABOLIC. That means you’ll keep all your gains while getting leaner. Will get you immediate, noticeable results: literally on the first dose. Provides one of the cleanest energies. It’s not a stimulant, so you won’t crash or feel anxious at all. The ability to run for as long as 12 weeks. You’ll get better and better results the longer you take it. Is versatile – can be stacked with virtually anything. Can be used while cutting or bulking. Cardarine will accelerate your results no matter what you do. Gives you an overall sense of health and wellbeing. You’ll feel amazing while you’re on it. No side effects, liver toxicity, or suppression have been reported. There’s no need for PCT either. Called the possible cure for obesity, Cardarine allows you to lose weight by using fat stores for energy rather than carbohydrates. Cardarine: The Cure for Obesity? THE PRIMARY ROLE is GW’s ability to rid the body of unwanted fatty tissue and it has become almost LEGENDARY. The chemical compounds in this particular PPAR agonist functions in differentiation of adipocytes. Much like growth hormone, GW 501516 generates proinflammatory markers in adipose tissue and decreasing the activity of genes involved in lipogenesis. This means that the body is able to block fatty acid chains from forming and being stored as fat. A study from Scientific Reports published in 2015 stated “GW501516 acts on PPAR beta cells that exclusively use body fat as energy in the same way the body would when going through “starvation mode”. The study is quoted stating: “physiological and pathophysiological functions of PPAR and generated novel strategies to treat metabolic diseases”. The activation of these particular genes in the body has been seen to burn body fat at such an alarming rate that it is being coined “the cure to obesity”. There were absolutely no adverse side effects detected in the last 20 years of study and it was extremely rare to see muscle wasting at any point during the research. Effects on Muscle Fibres The 2015 study by Wei Chen, PhD and his colleges has also found that dramatic increases in the PPAR gene in slow twitch muscle fibres increases oxygen usage and greatly increases endurance. The enhanced endurance was seen in lab mice with a normal oxygen supply and those with oxygen restrictions which provided significant evidence that GW501516 targets and enhances skeletal muscle endurance and recovery time to a supraphysiological level. A study titled “A metabolomics study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice” stated that BCAA were spared during trials of intense exercise which allowed the mice to have a greater rate of recovery in muscle tissue and neurotransmitters. These rats had even lost weight while maintaining a high fat diet, suggesting it could potentially prevent obesity and help manage weight regardless of eating habits. Recommendations & Dosing Guidelines for Cardarine 10-20 mg per day is a sufficient dose. It is recommended to start at 10mg per day to take advantage of the host’s sensitivity to the new chemical. 10 mg a day is aimed for endurance, and the higher the dosage the greater the fat loss benefits are going to be Lab mice should be given dosages 45 minutes- 1 hour before exercise. GW501516 has been tested for a 2 year study and has found no decreases or stagnation in effects. Most individuals run cycles for 12-14 weeks at a time with a 4-6 week break. This is normally to coincide with a SARM cycle, but there is no evidence showing that GW 501516 needs to be off-cycled after such a short amount of time. GW501516 was created for LONG TERM usage, so there is no reason why it shouldn’t be used that way. Half-life is between 16-24 hours and should be taken at 10mg once a day or 10mg once every 10-12 hours if taken at a higher dose. No PCT is needed, GW is recommended in combination with PCT if highly toxic anabolics have been used. Highly recommended to use with a ketogenic diet. Can be used in conjunction with anabolics and stimulants of any kind without adverse reactions. How GW 501516 Works GW 501516 Cardarine Chemical Composition GW stimulates glucose uptake and skeletal muscle tissue. It burns fat by stimulating fatty acid oxidation. It’s suggested as a potential treatment for obesity because of it’s ability to rapidly melt fat. Also, Cardarine is said to increase HDL by an average of 79% (good cholesterol) and decrease LDL (bad cholesterol) in current Phase II trials. GW 501516 is a PPARδ agonist. These help increase your HDL levels from an enhanced expression of the cholesterol transporter ABCA1. The Side Effects of GW 501516 Not to say that there are none, but in the last 20 years no side effects have been seen by anyone studying the drug. GW501516 has not only been tested in healthy subjects, but also those with simulated “real life” habits (such as drinking alcohol, stimulant narcotics, and the use of tobacco products). It is uncertain if there are long term ramifications, but no research has been published stating otherwise. This is what makes Cardarine so incredibly popular and usable over long periods of time. In certain studies, there have even been signs showing the reversal of diabetes, obesity, Dyslipidaemia and many other diseases. GW 501516 & Liver Damage In contrast to popular belief, GW501516 doesn’t promote damage of liver cells. The chemical has actually been known to promote healthy liver function and faster healing properties to the skin and muscle tissue. In essence, you will not heal rapidly like Wolverine from the X Men movies, but you will shorten your recovery time from scratches, blisters, and injured muscles by a significant amount. GW 501516 & Cancer There has been many forum comments expressing the concerns of GW501516 and its relationship to cancer and tumour development. The hypothesis for this controversy stems from GW’s ability to improve angiogenesis in the body at an extremely high rate and the rate of cancer growth in the colons of lab mice. Angiogenesis refers to the body’s ability to increase blood supply to feed the cells throughout the body. This is a common occurrence among endurance athletes and children going through adolescence. Scientist had speculation that if there were tumour cells active in the body, that they would be especially susceptible to angiogenesis and cause the tumour to grow at a much faster rate. Since 2004 many experiments have been done to prove this hypothesis, but so far, all of them have been largely unsuccessful. A study published in 2004 by the American Association of Cancer Research stated that PPAR agonists have “…shown to have no effect on the proliferation of colorectal cancer cells” and “…under normal culture conditions, PPAR activation has no effect on cell growth”. Keep in mind that this study was done in rats given amounts of 400 mg a day and was abused and ran for hundreds of weeks to top it all off. Time and time again this study has been refuted and shown to be deeply flawed and inaccurate. In a 2008 experiment done on human breast cancer and colon cancer cells, not only did the PPAR agonist GW 501516 prove to be safe for use, it has proven to inhibit cancer cell growth. The National Institute of Health has confirmed without a reasonable doubt that GW 501516 inhibits a multitude of cancers in human cells. Over a decade of research studies on human PPAR beta (the primary target of GW) has only proven a decrease in cancer cells with extended use (up to two years). The confusion for these previous allegations of cancer growth were from results published in 1996 and have long since been abandoned due to new clinical research. The chemical compound has been dosed in human PPAR for a number of years and has only provided positive results on cancer treatments, liver function, and metabolic efficiency. In all of the human studies done so far, there were no noticeable side effects at all while running GW. Check out some of the studies and resources on GW 501516 for more info: http://www.ncbi.nlm.nih.gov/pubmed/22814748 http://diabetes.diabetesjournals.org/content/57/2/332.long http://atvb.ahajournals.org/content/27/2/359.long Stacking GW 501516 Stacking Cardarine means running it in combination with other compounds. What makes Cardarine stand out is it can be used with almost anything (cutting, bulking or recomping). Bulking – clean up your gains and make that bulk cleaner while maintaining size. Cutting – totally optimal when it comes to weight loss while holding on to muscle mass. Recomping – perfect for building lean muscle and losing fat The most common way to use Cardarine is in a triple stack involving LGD 4033 and MK 2866. You’ll have all the gains, endurance, fat loss and size gains by taking all three.
Achieving the gains and other benefits that you get when you cycle with anabolic steroids and prohormones – while keeping clear from the nasty side effects that they can set off – has always been a dilemma for bodybuilders. This is the biggest reason why selective androgen receptor modulators or SARMS are taking the bodybuilding world by storm. They basically stimulate the same effects that prohormones and anabolic steroids can provide without making you vulnerable to sailing blood pressure levels, gynecomastia and even losing the gains that you’ve worked really hard for pumping iron. One SARM that is starting to gather quite a following nowadays is MK 677 (Nutrobal) and we’re going to give it a closer look shortly to see if it can really get the job done when it comes to helping you realize the bodybuilding goals you’ve got in your checklist. A Quick Lowdown on SARMS A SARM like MK 677 (Nutrobal) basically targets specific types of androgen receptors and alters the way they function in the body, which stimulates them to mimic the effects that anabolic steroids and prohormones can trigger. But what’s really interesting is you’re not going to be vulnerable to adverse side effects in the process. This is why SARMS like MK 677 are considered as game changers in the world of fitness and bodybuilding. How MK 677 (Nutrobal) Works Produced by Reverse Pharmacology, MK 677 (Nutrobal) is an orally administered growth hormone secretagogue that is designed to stimulate the pituitary gland to release growth hormones. In case you’re wondering, “secretagogue” is basically a natural substance that causes another substance to be secreted, such as gastrin. MK 677 (Nutrobal) was originally formulated to keep health problems like osteoporosis, obesity and muscle wasting, but has been seen to promote an increase in lean body mass as well as a boost in IGF-1 serum concentration during clinical runs. Moreover, here are the positive effects of MK 677 (Nutrobal) in terms of improving growth hormone pulse intensity: Inhibits the signaling of somatostatin receptors Slows down the activity of somastostatin in the system Improves somatotroph signaling in growth hormone releasing hormones (GHRH) Amplifies and increases the overall production and release of GHRH MK 677 (Nutrobal) Composition Here’s a look at the chemical composition of MK 677 (Nutrobal): MK 677 (Nutrobal) is rather similar to peptides like Ipamorelin and GHRP-6, but is administered orally and unlikely to set off the side effects that the latter can possibly cause during use. Apart from ease of use since you don’t have to do painful and inconvenient injections with MK 677 (Nutrobal), you can also expect to have significant changes in your IGF-1 and growth hormone levels while on the product. Recommended Dosage The ideal dose of taking MK 677 (Nutrobal) is between 5 to 25 milligrams daily in a 10-week cycle. Benefits of MK 677 (Nutrobal) Promotes the healing of ligaments, tendons, bones as well as old injuries Stimulates loose skin to tighten Promotes lean muscle mass Increases the oxidation of fat Possible Side Effects Akin to other products that stimulate the elevated amounts of growth hormones in the body, MK 677 (Nutrobal) can cause a slight increase in appetite, temporary bouts of lethargy and numb hands.
Ostarine, also known as MK-2866 is a SARM (selective androgen receptor module) created by GTx to avoid and treat muscle wasting. It can later on be a cure for avoiding atrophy (total wasting away of a body part), cachexia, sarcopenia and Hormone or Testosterone Replacement Therapy. This type of SARM cannot only retain lean body mass but as well as increase it. Ostarine is often mistaken as S1 but S1 was created earlier and is no longer going through more expansion. Benefits of Ostarine MK-2866 can give you: Increased lean mass gains Better strength More endurance Joint healing abilities Anabolic (even at doses as low as 3 mg) How Ostarine Works ostarine-chemical-structureOstarine (Ibutamoren) Chemical Structure SARMS bind to the androgen receptor (AR) and shows osteo (bone) and myo (muscular) selective anabolic activity. The tying and stimulation intensifies protein synthesis and builds muscle. Ostarine causes muscle growth just like steroids but it won’t produce negative side effects commonly found in anabolic steroids and prohormones such as prostate and other secondary sexual organs. MK-2866 uses its anabolic effects on muscle tissue fully so it’s not only a potential for curing muscle wasting ailments but also it has great potential for muscle building for athletes, bodybuilders and fitness buffs. It is also an agent to reduce degeneration during recovery times from serious surgery or similar conditions. *Ostarine has undergone 8 scientific trials by GTx with about 600 subjects plus 3 efficiency studies. A 4-month Phase IIb medical trial including 159 patients have shown a complete boost in total lean muscle mass compared to placebo and the secondary goal of increasing muscle strength. In terms of bodybuilding, Ostarine users have proven that MK-2866 can help improve lean muscle mass and strength levels. This guy’s overview might even explain everything about MK-2866 better… Uses of MK-2866 For Bulking Shines best when used for gaining lean muscle (bulking) as it is the most anabolic of all the SARMS. Suggested dosage is 25 mg for 4-6 weeks. PCT is not necessary. An increase of 6 lbs. of lean, keepable gains can be observed during this period. You can take Ostarine as high as 36 mg for 8 weeks BUT only if you weigh 210 lbs. Suppression is expected in higher doses so PCT after a cycle is a must. For Recomping Ostarine shines in recomping due to its nutrient portioning results. Calorie is used to build muscle which helps in weight loss and enhancing muscle mass and strength. Suggested dosing is 12.5-25 mg for 4-8 weeks. *Your diet must contain 30% of lean sources of protein to achieve the best recomp result. For Cutting MK-2866 can help cut whilst preserving muscle gains and decreasing calories. Suggested dosing is 12.5-15 mg for 4-6 weeks. Ostarine for Preventing Injuries The effects of MK-2866 convert to anabolism in bone and skeletal muscle tissue, which means it could be used in the future for different purposes such as osteoporosis and as a simultaneous treatment with drugs that decrease bone density. So, it has great use as a compound for injury recovery, specifically bone and tendon related injuries. Suggested dosage is 12.5 mg a day. Timing of Doses MK-2866 has a half-life of 24 hours. Each dose should be taken ONCE per day. Benefits of Ostarine to other SARMS (S4) Doesn’t have androgenic properties in non-muscle tissue. Metabolite M1 which causes changes in vision (common side effect in S4) isn’t found in Ostarine. Ostarine Side Effects MK-2866 is fully side effect free. The only threat is that it’s possible to experience some mild natural test shut down in cycles over 4 weeks, but the time between cycles are only 4 weeks.
In spite of being associated with SARMS, Stenabolic (SR9009) is in fact a Rev-ErbA ligand. It means SR binds to this protein and makes it more active. As a result, the user will experience a lot of positive effects, such as increased fat loss, enhanced endurance, and many other health benefits. Interestingly, it is one of the newest advances in pharmacology, but it is already getting more and more popularity among athletes all over the world. Therefore, in this article we will discuss what SR9009 is, how it works, and all the benefits it can offer to the user. What is Stenabolic (SR9009)? Also known as Stenabolic, SR9009 has been developed by Scripps Research Institute under the leadership of professor Thomas Burris. As mentioned beforehand, SR9009 is a synthetic Rev-Erb ligand, which is taken orally. This is a very unique compound. By stimulating the Rev-Erb protein, SR9009 has the ability to greatly influence a lot of regulatory mechanisms in the human body. For instance, it can affect the circadian rhythms, lipid and glucose metabolism, fat-storing cells, as well as macrophages. Hence, Stenabolic will allow the user to lose fat and drastically increase endurance, both of which are very desirable effects for an athlete. How it works By binding and activating the Rev-Erb protein, Stenabolic triggers a very wide range of processes in the body. The most prominent being the increase of mitochondria count in the muscles and an enhanced metabolism. As a consequence of the increased number of mitochondria in the muscles, the user will notice a drastic improvement in endurance and muscle strength. In fact, the mice used in studies could run 50% more when they were administered with SR9009, both in terms of distance and time. This is possible due to the fact that these mitochondria are precisely the ones generating energy in the body. Besides, thanks to the increase in number of macrophages, defective mitochondria are removed from the muscles and replaced with new ones. Furthermore, the change in metabolic rates increases energy expenditure by 5% even when the user is resting; hence, SR burns excess calories and doesn’t allow them to convert into fat. This, coupled with enhanced metabolism of glucose, helps effectively burn fat, which makes the body act is if it were in a constant state of exercise. To confirm this, we can see that according to studies, the activation of the Rev-Erb protein by Stenabolic leads to: “….decreased lipogenesis and cholesterol/bile acid synthesis in the liver, increased lipid and glucose oxidation in the skeletal muscle, and decreased triglyceride synthesis and storage in the WAT.” Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343186/ This means that less fat is stored, less cholesterol is developed by the liver, and more fat and glucose is burned in the muscles. However, these are not the only positive health effects seen with stenabolic. In fact, in the studies carried out with this compound it was found that it will decrease: Plasma triglycerides by 12% Total cholesterol by 47% Plasma non-esterified fatty acids by 23% Plasma glucose by 19% Plasma insulin level by 35% If that wasn’t enough, we need to mention that SR9009 will also decrease proinflammatory cytokine IL-6 by a whopping 72%, which will obviously be very beneficial for the reduction of inflammations. Medical uses Logically, with so many positive effects, SR9009 will have an extremely varied use in medicine. For instance, the drastic decrease in triglycerides and plasma glucose will be a huge help in the treatment of type 2 diabetes. What’s more, Stenabolic will be a crucial element in the treatment of sarcopenia – muscle and strength loss caused by aging. Additionally, SR9009 will allow doctors to treat obesity in those who for medical reasons cannot train or carry out any exercises, as it can replace exercise. Finally, it is very hard to overestimate its effectiveness in the treatment of cholesterol related conditions or metabolic syndromes. Uses in bodybuilding There is no need to be a genius to realize all the possibilities SR9009 opens to an athlete – amazing endurance and strength, fat loss, muscle hypertrophy (growth), improved cholesterol and blood sugar levels, and an increased metabolism. Hence, one can expect results similar to those seen with Cardarine (GW-501516), but with considerably more extra benefits. Besides, since stenabolic works great both solo or stacked, it will be a very good addition to any steroid or SARMS cycle, and it will give especially impressive results when used together with Cardarine. All in all, Stenabolic will allow you to do more cardio training, lift more, lose fat, gain lean muscle mass, and improve cholesterol levels. Cholesterol and cardio management is very important when using SR in combination with such steroids as Anavar or Trenbolone. Recommended dosages The optimal dosages range from 20 to 30 milligrams (mgs) per day. However, there is one drawback – due to a very short half life, you will need to space it out throughout the day for the best balance of the active substance in the body. Thus, it is best to use stenabolic every 2-4 hours, depending on the exact dosage used. For example, when the daily dosage is 30 mgs, you can take 10 mgs every 4 hours. Side Effects Up to now, no side effects have been observed with SR9009, so it may be seen as an extremely safe compound. Since Stenabolic is not a hormonal drug, it does not aromatize into estrogen and there is no suppression of natural testosterone production. Moreover, just like in the case of other SARMS, SR9009 is not liver toxic, but there is a need for liver supporting supplements when using it. N2Guard at 3-5 capsules per day will be sufficient liver and kidney support. Conclusion Stenabolic can be considered a major breakthrough in modern pharmacology, as it combines an incredible number of health benefits. Yet, it has no side effects to be concerned about. This Rev-Erb ligand will be extremely useful in medicine, and it is already successfully used in performance enhancement.
When it comes to stuff that have potent anabolic effects to pick up the pace on sculpting the physique you’ve always wanted, but without the adverse side effects of loading up on anabolic steroids and prohormones, selective androgen receptor modulators (SARMS) have already gathered quite a following among dedicated bodybuilders. One supplement that’s making waves these days is RAD 140 SARM and we’ll give it a closer look shortly to see if it can really help you get the job done. So How Does RAD 140 SARM Work? According to the Cambridge-based pharmaceuticals company Radius, the potent, orally bioavailable and nonsteroidal RAD 140 SARM is designed to make the hormonal receptors in the tissues of the body act the same way as if they’re getting a good dose of testosterone, setting off the same effects as if you’re cycling with prohormones and anabolic steroids minus unwanted side effects. Moreover, clinical studies also show that RAD 140 SARM also has a few other benefits, which we will discuss more thoroughly in a moment. The Benefits You’ll Get from RAD140 Akin to having an anabolic steroid and prohormone cycle, you’re going to have the following benefits when you use RAD 140 SARM: Enhanced speed, stamina and endurance during high-intensity workouts Faster buildup of muscular tissues that helps you achieve more gains in a shorter period of time Based on medical tests, RAD 140 SARM also displayed a greater anabolic effect than testosterone when used. Researchers pointed out that besides having a more “reinforced” effect than testosterone, RAD 140 SARM was also seen to help reduce the androgenic side effects that can be potentially caused by the same on the prostate. This makes its usage way safer and more effective compared to traditional prohormones and anabolic steroids available commercially. The Recommended Dosage for RAD140 Experts are still fine-tuning how much the ideal dosage is for RAD 140 SARM to maximize its benefits, particularly increasing lean body mass. The ongoing scientific studies are still verifying which among 0.3, 3 and 30 milligrams of RAD 140 SARM per day can help achieve the best results. Possible Side Effects of RAD140 Researchers point out that they still haven’t come across any adverse side effects that RAD 140 SARM can cause when used.